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Comment
. 2009 Jul;41(7):766-7.
doi: 10.1038/ng0709-766.

TET2 mutations in myelodysplasia and myeloid malignancies

Charles G Mullighan  1
Affiliations
Comment

TET2 mutations in myelodysplasia and myeloid malignancies

Charles G Mullighan. Nat Genet. 2009 Jul.

Abstract

The genetic basis of myelodysplasia has long been enigmatic, with few common targets of mutation known. A new study reports common mutations in the TET2 gene in myelodysplasia and related myeloid malignancies, suggesting that TET2 has an important role in hematopoiesis and in the pathogenesis of this disease.

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Comment on

  • Acquired mutations in TET2 are common in myelodysplastic syndromes.
    Langemeijer SM, Kuiper RP, Berends M, Knops R, Aslanyan MG, Massop M, Stevens-Linders E, van Hoogen P, van Kessel AG, Raymakers RA, Kamping EJ, Verhoef GE, Verburgh E, Hagemeijer A, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH. Langemeijer SM, et al. Nat Genet. 2009 Jul;41(7):838-42. doi: 10.1038/ng.391. Epub 2009 May 31. Nat Genet. 2009. PMID: 19483684

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