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Case Reports
. 2009 May-Jun;22(3):417-20.

Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis

Daisuke Son  1 , Hiroko Kanda, Akihiro Yamaguchi, Kimito Kawabata, Takahisa Kawakami, Kanae Kubo, Mana Higashihara, Jun Shimizu, Hiroshi Uozaki, Shigeru Kuramochi, Yoshikata Misaki, Fujio Takeuchi, Kazuhiko Yamamoto
Affiliations
  • PMID: 19557721
Case Reports

Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis

Daisuke Son et al. J Nephrol. 2009 May-Jun.

Abstract

Renal involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by focal segmental crescentic and/or necrotizing glomerulonephritis. Here, we report the case of a 66-year-old woman showing myeloperoxidase (MPO)-ANCA positivity and mononeuritis multiplex whose kidney biopsy revealed severe and diffuse tubulointerstitial nephritis despite the fact that crescentic necrotizing glomerulonephritis was focal. The mechanism of tubulointerstitial injury in ANCA-associated vasculitis remains unclear. Further studies are necessary to confirm the relationship between diffuse tubulointerstitial nephritis and ANCA-associated vasculitis.

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