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. 2009 Nov;29(11):1224-31.
doi: 10.1111/j.1468-2982.2009.01855.x. Epub 2009 Apr 9.

Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura

P Tikka-Kleemola  1 , M A Kaunisto, E Hämäläinen, U Todt, H Göbel, J Kaprio, C Kubisch, M Färkkilä, A Palotie, M Wessman, M Kallela
Affiliations

Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura

P Tikka-Kleemola et al. Cephalalgia. 2009 Nov.

Abstract

The effect of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura (MA) susceptibility is not established yet. We studied the association between the MA end-diagnosis and three migraine trait components and 32 single nucleotide polymorphisms (SNPs) capturing the variation of endothelin genes in 850 Finnish migraine patients and 890 non-migrainous individuals. The SNPs showing evidence of association were further studied in 648 German migraine patients and 651 non-migrainous individuals. No significant association was detected. However, the homozygous minor genotype (5% in cases) of the EDNRA SNP rs2048894 showed nominal association with MA both in the Finnish sample (P = 0.015) and in the pooled sample [odds ratio (OR) 1.61, 95% confidence interval (CI) 1.12-2.32, P = 0.010] when adjusted for gender and sample origin. The trait age of onset < 20 years was also associated with rs2048894 (OR 1.69, 95% CI 1.13-2.54, P = 0.011) in the pooled sample. To confirm this finding studies on even larger samples are required.

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Figures

Figure 1
Figure 1
Linkage disequilibrium (LD) plots of EDN1 (a), EDNRA (b) and EDNRB (c) genes defined by single nucleotide polymorphisms (SNPs) genotyped in the Finnish control subjects. Chromosomal locations of these genes with their coding regions are shown above the LD plots. The pair-wise LD adjusted for allele frequencies (r2 value) is shown as different shadings of grey. The haploblocks were identified with the confidence interval algorithm implemented in the Haploview program that uses the D’ LD statistics. In the figure the haploblocks are circled with a black line. Tagging SNPs that capture the variation within haploblocks are marked with black triangles above the SNP identifiers.
See this image and copyright information in PMC

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