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. 1977 Jul 14;468(2):188-93.
doi: 10.1016/0005-2736(77)90113-4.

Cyclic AMP modulation of calcium accumulation by sarcoplasmic reticulum from fast skeletal muscle

E P Bornet, M L Entman, W B Van Winkle, A Schwartz, D C Lehotay, G S Levey

Cyclic AMP modulation of calcium accumulation by sarcoplasmic reticulum from fast skeletal muscle

E P Bornet et al. Biochim Biophys Acta. .

Abstract

The role of cyclic 3',5'-AMP in modulating sarcoplasmic reticulum from fast skeletal muscle was studied. The rate of Ca2+ uptake was stimulated in the presence of protein kinase plus 1 micron cyclic AMP. The stimulation was absent when denatured protein kinase was used. When an adenylate cyclase inhibitor was added, the uptake rates fell to 55% of control. This decrease in rate was partially overcome by 1 micron cyclic AMP. A modulating role for cyclic AMP in fast skeletal muscle is proposed.

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