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Clinical Trial
. 2009 Jul;28(7):653-5.
doi: 10.1097/INF.0b013e3181998f06.

A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella

Anne A Gershon  1 , Myron J Levin, Adriana Weinberg, Lin-Yee Song, Philip S LaRussa, Sharon P Steinberg, Patterson Bartlett; Pediatric AIDS Clinical Trials Group 391 Team
Collaborators, Affiliations
Clinical Trial

A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella

Anne A Gershon et al. Pediatr Infect Dis J. 2009 Jul.

Abstract

Herpes zoster, may be severe and recurrent in HIV-infected children. We determined the safety and immunogenicity of live attenuated varicella-zoster virus (VZV) vaccine in 46 HIV-infected children who had experienced varicella. There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster.

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References

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