Necrotizing vasculitis as a complication of propylthiouracil
- PMID: 19561747
- PMCID: PMC2672274
Necrotizing vasculitis as a complication of propylthiouracil
Abstract
Background: Acute dermatologic conditions are a concern for acute care practitioners. Comprising 1.4% of presenting complaints to emergency departments, most skin complaints are relatively benign; however, some conditions can be quite severe. Prompt diagnosis is essential to avoid unnecessary morbidity and mortality.
Objectives: To review drug-induced vasculitis.
Case report: We present the case of a 43-year-old female with a chief complaint of bruising to her ear, arm, and leg. She was found to have necrotizing vasculitis induced by propylthiouracil.
Conclusion: In this case, we look at the highlights of this presentation and review key aspects of cutaneous vasculitis for the practicing emergency provider.
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References
-
- McCaig L, Nawar E. National hospital ambulatory medical care survey: 2004 emergency department survey. CDC Advance Data. Vital and Health Statistics. 2006;372 - PubMed
-
- Dubost JJ, Souteyrand P, Sauvezie B. Drug-induced vasculitides. Baillieres Clin Rheumatol. 1991;5:119–138. - PubMed
-
- Ekenstam E, Callen JP. Cutaneous leukocytoclastic vasculitis. Clinical and laboratory features of 82 patients seen in private practice. Arch Dermatol. 1984;120:484–489. - PubMed
-
- Otsuka S, Kinebuchi A, Tabata H, Yamakage A, Yamazaki S. Myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis following propylthiouracil therapy. Br J Dermatol. 2000;142:828–830. - PubMed
-
- Carlson JA, Ng BT, Chen KR. Cutaneous vasculitis update: diagnostic criteria, classification, epidemiology, etiology, pathogenisis, evaluation and prognosis. Am J Dermatopathol. 2005;27:504–528. - PubMed
