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Case Reports
. 2008 Apr;3(2):64-6.
doi: 10.4103/1817-1737.39640.

Extramedullary paraspinal hematopoiesis in hereditary spherocytosis

P Gogia  1 , R Goel, S Nayar
Affiliations
Case Reports

Extramedullary paraspinal hematopoiesis in hereditary spherocytosis

P Gogia et al. Ann Thorac Med. 2008 Apr.

Abstract

Hereditary spherocytosis (HS) is a common inherited hemolytic anemia due to red cell membrane defects. Extramedullary hematopoiesis is a compensatory response to insufficient bone marrow blood cell production. The preferred sites of extramedullary hematopoietic involvement are the spleen, liver and lymph nodes; but in HS, the posterior paravertebral mediastinum is also commonly involved. We report a case of a 50-year-old male who presented to us in respiratory distress and with bilateral paravertebral posterior mediastinal masses, which on trucut biopsy were found to be extra-hematopoietic masses; and the patient was found to have hereditary spherocytosis.

Keywords: Extramedullary hematopoiesis; hereditary spherocytosis; posterior mediastinal masses.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Chest X ray showing a bilateral mass lesions
Figure 2
Figure 2
CECT thorax showing hypodense mass, seen in the posterior mediastinum involving bilateral paravertebral region extending from carina to diaphragm with right-sided pneumothorax with collapse of underlying lung
Figure 3
Figure 3
CT-guided biopsy from lung lesion showing hyperplastic erythroid bone marrow
See this image and copyright information in PMC

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