Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009;14(4):670-8.
doi: 10.2478/s11658-009-0027-z. Epub 2009 Jun 27.

Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells

Ya-Jun Liu  1 , Dao-Qiang Zhang, Xiu-Mei Sui, Wei Tian
Affiliations

Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells

Ya-Jun Liu et al. Cell Mol Biol Lett. 2009.

Abstract

Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression and metastasis. Here, we show that the overexpression of OPN in human embryo kidney-293 cells significantly increases both the level of cell proliferation, by provoking the G(1)/S transition, and the level of cell migration in vitro. These findings suggest that augmented OPN contributes to cell growth and motility. Inhibiting OPN or the pathway it stimulates may therefore represent a novel approach for the treatment of primary tumors and associated metastases.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Ramaiah S.K., Rittling S. Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol. Sci. 2008;103:4–13. doi: 10.1093/toxsci/kfm246. - DOI - PubMed
    1. Rangaswami H., Bulbule A., Kundu G.C. Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol. 2006;16:79–87. doi: 10.1016/j.tcb.2005.12.005. - DOI - PubMed
    1. Rittling S.R., Chambers A.F. Role of osteopontin in tumour progression. Br. J. Cancer. 2004;90:1877–1881. doi: 10.1038/sj.bjc.6601839. - DOI - PMC - PubMed
    1. Haqq C., Nosrati M., Sudilovsky D., Crothers J., Khodabakhsh D., Pulliam B.L., Federman S., Miller J.R., 3rd, Allen R.E., Singer M.I., Leong S.P., Ljung B.M., Sagebiel R.W., Kashani-Sabet M. The gene expression signatures of melanoma progression. Proc. Natl. Acad. Sci. USA. 2005;102:6092–6097. doi: 10.1073/pnas.0501564102. - DOI - PMC - PubMed
    1. Fedarko N.S., Jain A., Karadag A., Van Eman M.R., Fisher L.W. Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clin. Cancer Res. 2001;7:4060–4066. - PubMed