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Case Reports
. 2009;39(7):619-23.
doi: 10.1007/s00595-008-3884-6. Epub 2009 Jun 28.

Primary adenosquamous carcinoma of the colon: report of five cases

Yingchun Dong  1 , Jiandong Wang, Henghui Ma, Hangbo Zhou, Guangming Lu, Xiaojun Zhou
Affiliations
Case Reports

Primary adenosquamous carcinoma of the colon: report of five cases

Yingchun Dong et al. Surg Today. 2009.

Abstract

Primary adenosquamous cell carcinomas (Ad-SCCs) of the colon and rectum are rare malignancies with a poor prognosis, in comparison to adenocarcinoma alone. Different roles of human papilloma virus (HPV) in its pathogenesis have been reported and the role of P16 in Ad-SCCs has not been explored. This report presents five cases of Ad-SCC of the colon to explore the clinicopathological features and the roles of P16, HPV 6/11, and 16/18. There was no confirmed evidence to support the relationship between the infection of HPV 6/11, 16/18, and pathogenesis of Ad-SCC of the colon. P16 overexpression was not related to HPV carcinogenesis and there might be another mechanism of P16 upregulation in Ad-SCC of the colon.

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