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. 2009 Mar:92 Suppl 2:S57-60.

Non-diabetic glomerular disease in type II DM: 10 years experience

Orapin Chawarnkul  1 , Kriengsak Vareesangthip, Leena Ongajyooth, Bunyarit Cheunsuchon, Paisal Parichatikanond
Affiliations
  • PMID: 19562987

Non-diabetic glomerular disease in type II DM: 10 years experience

Orapin Chawarnkul et al. J Med Assoc Thai. 2009 Mar.

Abstract

Background: The nature of renal damage in patients with type II diabetes remains unclear.

Objective: To analyze the renal histopathology in type II diabetes who underwent renal biopsy at Siriraj Hospital, renal unit over 10 year period.

Material and method: The clinical and biochemical data in 54 patients with Type II DM, atypical cases of DN, were subjected to renal biopsy and analyzed retrospectively.

Results: Ten out of fifty-four type II diabetic patients (18.5%) were diagnosed non-diabetic nephropathy (NDN); there were 4 patients with membranous GN, 3 patients with crescentic GN1 patient of MPGN type I, 1 patient with renal change from hypertension and 1 patient with IgMN. The most important factor that had statistically significant was nephritis urine sediment (NDN: DN 40% vs. 4.5%), However 60% of NDN had no nephritic urine sediment.

Conclusion: There was no strong predictor to differentiate DN from NDN by clinical or biochemical data. The only significant finding in NDN was nephritic urine sediment.

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