GABA keeps up an appetite for life
- PMID: 19563747
- DOI: 10.1016/j.cell.2009.06.002
GABA keeps up an appetite for life
Abstract
In the arcuate nucleus of the hypothalamus, neurons that produce the neuropeptides NPY and AgRP play a vital role in the maintenance of energy homeostasis. In this issue, Wu et al. (2009) show that these neurons modulate feeding behavior in mice by providing GABAergic input to the parabrachial nucleus in the brainstem.
Comment on
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Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation.Cell. 2009 Jun 26;137(7):1225-34. doi: 10.1016/j.cell.2009.04.022. Cell. 2009. PMID: 19563755 Free PMC article.
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