Comment
doi: 10.1016/j.cell.2009.06.008.
The juxtamembrane region of EGFR takes center stage
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- PMID: 19563749
- DOI: 10.1016/j.cell.2009.06.008
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Comment
The juxtamembrane region of EGFR takes center stage
Cell.
.
Free article
Abstract
The activation process for the epidermal growth factor receptor (EGFR) involves formation of an asymmetric dimer of the tyrosine kinase domains. Jura et al. (2009) in this issue and Brewer et al. (2009) in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in stabilizing this dimer.
Comment on
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Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.Cell. 2009 Jun 26;137(7):1293-307. doi: 10.1016/j.cell.2009.04.025. Cell. 2009. PMID: 19563760 Free PMC article.
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