Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1991 Dec 5;354(6352):369-73.
doi: 10.1038/354369a0.

Structure and functional properties of human general transcription factor IIE

M G Peterson  1 , J Inostroza, M E Maxon, O Flores, A Admon, D Reinberg, R Tjian
Affiliations
Comparative Study

Structure and functional properties of human general transcription factor IIE

M G Peterson et al. Nature. .

Abstract

The general transcription factor IIE (TFIIE) is an essential component of the eukaryotic RNA polymerase II initiation complex. We have isolated human complementary DNA clones for both the subunits of TFIIE. Using purified recombinant proteins we find that both subunits are essential to form a stable preinitiation complex and to reconstitute basal-level and Sp1-activated transcription in vitro. Analysis of their predicted amino-acid sequences reveals several intriguing structural motifs that could provide insight into the role of TFIIE in transcription initiation.

PubMed Disclaimer

Publication types

LinkOut - more resources