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. 2009 Aug 15;19(16):4786-9.
doi: 10.1016/j.bmcl.2009.06.049. Epub 2009 Jun 17.

Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential

Priyankar Paira  1 , Abhijit Hazra, Shrabanti Kumar, Rupankar Paira, Krishnendu B Sahu, Subhendu Naskar, Pritam Saha, Shyamal Mondal, Arindam Maity, Sukdeb Banerjee, Nirup B Mondal
Affiliations

Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential

Priyankar Paira et al. Bioorg Med Chem Lett. .

Abstract

Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione (isatin) with differently substituted indoles and pyrrole in presence of I(2) in i-PrOH. The in vitro spermicidal potentials and the mode of spermicidal action of the synthesized analogues were evaluated and the derivative, 3,3-bis (5-methoxy-1H-indol-3-yl) indolin-2-one (3d) exhibited most significant activity.

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