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Comment
. 2009 Jul;58(7):1482-4.
doi: 10.2337/db09-0622.

Brown fat in humans: turning up the heat on obesity

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Comment

Brown fat in humans: turning up the heat on obesity

Patrick Seale et al. Diabetes. 2009 Jul.
No abstract available

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Figures

FIG. 1.
FIG. 1.
BAT contributes to energy expenditure. Weight gain and obesity are caused by chronic periods of positive energy balance. Energy intake comes from food consumption, whereas the major contributors to expenditure are exercise and basic metabolic processes. The studies reviewed here suggest that BAT activity could impact daily energy expenditure. BAT dissipates energy as heat and can thus counteract weight gain. Interindividual variability in the amount or function of this tissue may impact body weight. In addition, therapeutic expansion/activation of this tissue may prove to be an effective therapy for obesity. WAT, white adipose tissue.

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References

    1. Bray GA, Bellanger T: Epidemiology, trends, and morbidities of obesity and the metabolic syndrome. Endocrine 2006; 29: 109– 117 - PubMed
    1. Cannon B, Nedergaard J: Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277– 359 - PubMed
    1. Seale P, Kajimura S, Spiegelman BM: Transcriptional control of brown adipocyte development and physiological function–of mice and men. Genes Dev 2009; 23: 788– 797 - PMC - PubMed
    1. Astrup A, Bulow J, Madsen J, Christensen NJ: Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. Am J Physiol 1985; 248: E507– E515 - PubMed
    1. Cunningham S, Leslie P, Hopwood D, Illingworth P, Jung RT, Nicholls DG, Peden N, Rafael J, Rial E: The characterization and energetic potential of brown adipose tissue in man. Clin Sci (Lond) 1985; 69: 343– 348 - PubMed

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