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Comment
. 2009 Aug;182(4):1397-8.
doi: 10.1534/genetics.109.106146. Epub 2009 Jun 29.

Public health implications of epigenetics

Adam E Handel, Sreeram V Ramagopalan
Comment

Public health implications of epigenetics

Adam E Handel et al. Genetics. 2009 Aug.
No abstract available

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Figures

F<sc>igure</sc> 1.—
Figure 1.—
Intervention at different time points after exposure to an epigenetically active environmental factor. Slatkin's model of epigenetic inheritance is used, with the probability for epigenetic alteration at a hypothetical locus (β) initially 0.2 and the probability of transgenerational loss of the epigenetic mark (α) 0.05 as described (Slatkin 2009). Time is measured in generations (for human populations ∼25 years) and exposure occurs when t = 0. The vertical axis is the population frequency of the epigenetic mark. Intervention to limit exposure (modeled as β becoming 0) occurs after different generations following exposure (see key). Note that these numbers are arbitrary as α and β have never been experimentally determined.
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