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. 2009 Jul 16;361(3):225-9.
doi: 10.1056/NEJMp0904819. Epub 2009 Jun 29.

The persistent legacy of the 1918 influenza virus

David M Morens  1 , Jeffery K Taubenberger, Anthony S Fauci
Affiliations

The persistent legacy of the 1918 influenza virus

David M Morens et al. N Engl J Med. .

Erratum in

  • N Engl J Med. 2009 Sep 10;361(11):1123
No abstract available

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Figures

None
Genetic Relationships among Human and Relevant Swine Influenza Viruses, 1918-2009
Yellow arrows reflect exportation of one or more genes from the avian influenza A virus gene pool. The dashed red arrow indicates a period without circulation. Solid red arrows indicate the evolutionary paths of human influenza virus lineages; solid blue arrows, of swine influenza virus lineages; and the blue-to-red arrow, of a swine-origin human influenza virus. All influenza A viruses contain eight genes that encode the following proteins (shown from top to bottom within each virus): polymerase PB2, polymerase PB1, polymerase PA, hemagglutinin (HA), nuclear protein (NP), neuraminidase (NA), matrix proteins (M), and nonstructural proteins (NS). The genes of the 1918 human and swine H1N1 and the 1979 H1N1 influenza A viruses were all recently descended from avian influenza A genes, and some have been “donated” to the pandemic human H1N1 strain.
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