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. 2009 Jul 21;9(14):1991-3.
doi: 10.1039/b903388b. Epub 2009 May 28.

Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells

Ryota Kojima  1 , Keitaro Yoshimoto, Emiko Takahashi, Masahiro Ichino, Hirotoshi Miyoshi, Yukio Nagasaki
Affiliations

Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells

Ryota Kojima et al. Lab Chip. .

Abstract

A spheroid array of fetal mouse liver cells, which comprise various immature cells, was constructed on a PEG-gel micropatterned surface and its hepatic activity and degree of differentiation induction were significantly upregulated by co-culture with nonparenchymal liver cells as feeder-cells.

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