Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jul 2;361(1):86-8.
doi: 10.1056/NEJMcibr0903347.

Cardiomyocyte renewal

Michael S Parmacek  1 , Jonathan A Epstein
Affiliations

Cardiomyocyte renewal

Michael S Parmacek et al. N Engl J Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Epstein reports receiving lecture fees from GlaxoSmithKline. No other potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Therapeutic Approaches to Cardiac Regeneration
The demonstration that some cardiomyocytes are regenerated after birth highlights the promise and challenges of future regenerative cardiac therapies. Autologous and allogeneic sources of cells that may give rise to cardiomyocytes are under investigation.
See this image and copyright information in PMC

References

    1. Bergmann O, Bhardwaj RD, Bernard S, et al. Evidence for cardiomyocyte renewal in humans. Science. 2009;324:98–102. - PMC - PubMed
    1. Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science. 2002;298:2188–90. - PubMed
    1. Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–5. - PubMed
    1. Cai CL, Martin JC, Sun Y, et al. A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008;454:104–8. - PMC - PubMed
    1. Parmacek MS, Epstein JA. Pursuing cardiac progenitors: regeneration redux. Cell. 2005;120:295–8. - PubMed