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Meta-Analysis
. 2009;28(3):220-6.
doi: 10.1159/000226773. Epub 2009 Jul 2.

Elevated troponin after stroke: a systematic review

Gillian Kerr  1 , Gautamananda Ray, Olivia Wu, David J Stott, Peter Langhorne
Affiliations
Meta-Analysis

Elevated troponin after stroke: a systematic review

Gillian Kerr et al. Cerebrovasc Dis. 2009.

Abstract

Background: Troponin levels are elevated in some acute stroke patients, but the clinical significance of this is unclear.

Methods: We conducted a systematic review of studies measuring troponin within 7 days of symptom onset in acute stroke patients.

Results: We identified 15 studies (2,901 patients). Overall 18.1% (95% CI 13.6-22.6) had a positive troponin level. These patients were more likely to have electrocardiogram (ECG) changes suggestive of myocardial ischemia (OR 3.0; 95% CI 1.5-6.2), and there was an independent association with death (OR 2.9; 95% CI 1.7-4.8).

Conclusion: Elevated troponin level after acute stroke is common and is associated with ECG changes suggestive of myocardial ischemia and increased risk of death.

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