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. 2009 Jul 2;460(7251):49-52.
doi: 10.1038/nature08180.

Elite and stochastic models for induced pluripotent stem cell generation

Shinya Yamanaka  1
Affiliations

Elite and stochastic models for induced pluripotent stem cell generation

Shinya Yamanaka. Nature. .

Abstract

Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.

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