Review
doi: 10.1016/0968-0004(91)90121-b.
Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition
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- PMID: 1957350
- DOI: 10.1016/0968-0004(91)90121-b
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Review
Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition
Trends Biochem Sci.
1991 Aug.
Abstract
The highly conserved DNA-binding domain of the steroid hormone receptors contains two 'zinc finger'-like sequence motifs. The three-dimensional structure in solution has been determined using two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy and shows that the two 'zinc finger'-like motifs fold to form a single structural domain. The combination of this structural information and mutagenesis data reveals how this family of transcriptional regulators bind to DNA.
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