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. 1977 Jun 6;284(21):2139-42.

[Intestinal vasoactive peptide receptors in enterocytes : specific binding and stimulation of cyclic AMP]

[Article in French]
M Laburthe, J Besson, D H Bon Hoa, G Rosselin
  • PMID: 195749

[Intestinal vasoactive peptide receptors in enterocytes : specific binding and stimulation of cyclic AMP]

[Article in French]
M Laburthe et al. C R Acad Hebd Seances Acad Sci D. .

Abstract

Receptors for the vasoactive intestinal peptide (VIP) were characterized on enterocytes isolated from Rat small intestine. Native VIP inhibited competitively the binding of 125I-VIP to enterocytes and strongly stimulated cyclic AMP production; both these effects were observed for concentrations of VIP as low as 0.5-1.0 ng/ml (0.15-0.30 nM) which are compatible with the VIP concentration in the gut.

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