Gene Ontology for type III effectors: capturing processes at the host-pathogen interface

Abstract

Disease development is determined by the interplay of host defense processes and pathogen factors that subvert defenses and remodel the host for parasitic benefit. The goal of the Plant-Associated Microbe Gene Ontology (PAMGO) interest group is the development of Gene Ontology (GO) terms that capture the range of biological processes occurring between hosts and symbionts (from mutualists to pathogens). Here, the application of the new GO terms to type III effector proteins (T3Es) from the plant pathogen Pseudomonas syringae serves as an example to systematically document the available extensive data and to reveal shared aspects of interactions with various host plants. Extending the comparison to T3Es deployed by animal pathogens further highlights how GO can uncover the common strategies employed by diverse symbionts as they exploit the host niche. Future application of GO terms to gene products mediating pathogenic or mutualistic interactions involving other microbes will enhance researchers' abilities to identify fundamental patterns among diverse systems and generate new hypotheses based on associations among annotations.