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. 2009 Jul 29;131(29):9886-7.
doi: 10.1021/ja903573p.

Pd(0)/PR3-catalyzed intermolecular arylation of sp3 C-H bonds

Masayuki Wasa  1 , Keary M Engle, Jin-Quan Yu
Affiliations

Pd(0)/PR3-catalyzed intermolecular arylation of sp3 C-H bonds

Masayuki Wasa et al. J Am Chem Soc. .

Abstract

Pd(0)-catalyzed intermolecular arylation of sp(3) C-H bonds has been achieved using PR(3)/ArI. This protocol can be used to arylate a variety of aliphatic carboxylic acid derivatives, including a number of bioactive drug molecules. The use of fluorinated aryl iodides also allows for the introduction of fluorine into a molecule of interest.

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Figures

Figure 1
Figure 1
Possible Coordination Modes
Scheme 1
Scheme 1
Pd(0)-Catalyzed Arylation of C–H Bonds
See this image and copyright information in PMC

References

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