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Editorial
. 2009 Jul 21;120(3):190-3.
doi: 10.1161/CIRCULATIONAHA.109.876607. Epub 2009 Jul 6.

Assays for S-nitrosothiols and S-nitrosylated proteins and mechanistic insights into cardioprotection

Douglas T Hess, Matthew W Foster, Jonathan S Stamler
Editorial

Assays for S-nitrosothiols and S-nitrosylated proteins and mechanistic insights into cardioprotection

Douglas T Hess et al. Circulation. .
No abstract available

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Conflict of interest statement

Disclosures

Dr Stamler owns equity in LifeHealth, a company developing assays for the detection of NO-based molecules. The remaining authors report no conflicts.

Figures

Figure
Figure
NO-based mechanisms for preconditioning in ischemia/reperfusion injury. Accumulating evidence suggests a role for NO/SNO in estrogen and adrenergic receptor–mediated and statin-induced preconditioning in ischemia/reperfusion injury. Protein S-nitrosylation, resulting from increased NOS expression and activity and altered subcellular localization, appears to be a principal mediator of these effects.
See this image and copyright information in PMC

Comment on

References

    1. Konhilas JP, Leinwand LA. The effects of biological sex and diet on the development of heart failure. Circulation. 2007;116:2747–2759. - PubMed
    1. Jones SP, Bolli R. The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol. 2006;40:16–23. - PubMed
    1. Lin J, Steenbergen C, Murphy E, Sun J. Estrogen receptor-β activation results in S-nitrosylation of proteins involved in cardioprotection. Circulation. 2009;120:245–254. - PMC - PubMed
    1. Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS. Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol. 2005;6:150–166. - PubMed
    1. Sun J, Picht E, Ginsburg KS, Bers DM, Steenbergen C, Murphy E. Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel α1 subunit and reduced ischemia/reperfusion injury. Circ Res. 2006;98:403–411. - PubMed

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