Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2009 Jul 21;120(3):212-20.
doi: 10.1161/CIRCULATIONAHA.108.846519. Epub 2009 Jul 6.

Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study

Sarah Rosner Preis  1 , Michael J Pencina, Shih-Jen Hwang, Ralph B D'Agostino Sr, Peter J Savage, Daniel Levy, Caroline S Fox
Affiliations
Comparative Study

Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study

Sarah Rosner Preis et al. Circulation. .

Abstract

Background: Individuals with diabetes mellitus are at 2- to 3-fold increased risk for cardiovascular disease (CVD) relative to those without diabetes. Our objective was to examine CVD risk factor level changes among individuals with and without type 2 diabetes mellitus from 1970 to 2005 in the Framingham Heart Study.

Methods and results: We included 4195 participants (3990 with no diabetes and 205 with diabetes) 50 years of age and 3495 participants (3178 with no diabetes and 317 with diabetes) 60 years of age. Contemporaneous CVD risk factor levels were measured; linear regression models were used to assess the interaction between diabetes status and calendar year on CVD risk factor levels. Among 50-year-olds without diabetes mellitus, there was an increase in body mass index of 0.39 kg/m(2) per 10 years, whereas for those with diabetes, there was an increase of 2.52 kg/m(2) (P value for the diabetes-by-calendar year interaction [P for interaction] <0.001). For low-density lipoprotein cholesterol, the mean decrease was -7.43 mg/dL per decade (nondiabetes) and -15.5 mg/dL for diabetes (P for interaction=0.002). For systolic blood pressure, the mean decrease was -3.35 mm Hg per decade (nondiabetes) and -3.50 mm Hg for diabetes (P for interaction=0.97). The direction of the trends for those with diabetes relative to those without diabetes was similar for 60-year-olds.

Conclusions: Compared with individuals without diabetes mellitus, individuals with diabetes experienced a greater increase in body mass index, a greater decrease in low-density lipoprotein cholesterol, and a similar magnitude of decline in systolic blood pressure. Individuals with diabetes mellitus have not experienced the necessary declines in CVD risk factors to overcome their increased risk of CVD. Further efforts are needed to aggressively control CVD risk factors among individuals with diabetes mellitus.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 1a. Sex-adjusted mean BMI by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005. Figure 1b. Sex-adjusted mean total and LDL cholesterol levels by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005. Figure 1c. Sex-adjusted mean systolic and diastolic blood pressure levels by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005.
Figure 1
Figure 1
Figure 1a. Sex-adjusted mean BMI by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005. Figure 1b. Sex-adjusted mean total and LDL cholesterol levels by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005. Figure 1c. Sex-adjusted mean systolic and diastolic blood pressure levels by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005.
Figure 1
Figure 1
Figure 1a. Sex-adjusted mean BMI by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005. Figure 1b. Sex-adjusted mean total and LDL cholesterol levels by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005. Figure 1c. Sex-adjusted mean systolic and diastolic blood pressure levels by decade among participants with and without diabetes (DM) in the Framingham Heart Study, 1970–2005.
See this image and copyright information in PMC

References

    1. Shepherd J, Barter P, Carmena R, Deedwania P, Fruchart JC, Haffner S, Hsia J, Breazna A, LaRosa J, Grundy S, Waters D. Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to New Targets (TNT) study. Diabetes Care. 2006;29:1220–1226. - PubMed
    1. Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, Menard J, Rahn KH, Wedel H, Westerling S. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998;351:1755–1762. - PubMed
    1. Collins R, Armitage J, Parish S, Sleigh P, Peto R. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet. 2003;361:2005–2016. - PubMed
    1. Saaddine JB, Engelgau MM, Beckles GL, Gregg EW, Thompson TJ, Narayan KM. A diabetes report card for the United States: quality of care in the 1990s. Ann Intern Med. 2002;136:565–574. - PubMed
    1. Saydah SH, Fradkin J, Cowie CC. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA. 2004;291:335–342. - PubMed

Publication types

Substances