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Review
. 2009 Aug;13(8A):1464-75.
doi: 10.1111/j.1582-4934.2009.00837.x. Epub 2009 Jul 6.

The immune boundaries for stem cell based therapies: problems and prospective solutions

Abdelkrim Hmadcha  1 , Juan Domínguez-Bendala, Jane Wakeman, Mohamed Arredouani, Bernat Soria
Affiliations
Review

The immune boundaries for stem cell based therapies: problems and prospective solutions

Abdelkrim Hmadcha et al. J Cell Mol Med. 2009 Aug.

Erratum in

  • J Cell Mol Med. 2009 Aug;13(8B):2754. Abdelkrim, Hmadcha [corrected to Hmadcha, Abdelkrim]; Juan, Domínguez-Bendala [corrected to Domínguez-Bendala, Juan]; Jane, Wakeman [corrected to Wakeman, Jane]; Mohamed, Arredouani [corrected to Arredouani, Mohamed]; Bernat, Soria [corrected to Soria, B

Abstract

Stem cells have fascinated the scientific and clinical communities for over a century. Despite the controversy that surrounds this field, it is clear that stem cells have the potential to revolutionize medicine. However, a number of significant hurdles still stand in the way of the realization of this potential. Chiefly among these are safety concerns, differentiation efficiency and overcoming immune rejection. Here we review current progress made in this field to optimize the safe use of stem cells with particular emphasis on prospective interventions to deal with challenges generated by immune rejection.

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