Revealing tumor immunity after hematopoietic stem cell transplantation
- PMID: 19584145
- DOI: 10.1158/1078-0432.CCR-09-0873
Revealing tumor immunity after hematopoietic stem cell transplantation
Abstract
Allogeneic hematopoietic stem cell transplantation is currently the most effective method for inducing tumor immunity. However, the diversity of target antigens recognized by donor T cells has not been established. New studies show that tumor-reactive T cells are directed against diverse tumor-specific targets as well as minor histocompatibility antigens.
Comment on
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Development of tumor-reactive T cells after nonmyeloablative allogeneic hematopoietic stem cell transplant for chronic lymphocytic leukemia.Clin Cancer Res. 2009 Jul 15;15(14):4759-68. doi: 10.1158/1078-0432.CCR-09-0199. Epub 2009 Jun 30. Clin Cancer Res. 2009. PMID: 19567591 Free PMC article.
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