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. 1991 Oct;32(4):508-11.
doi: 10.1111/j.1365-2125.1991.tb03940.x.

Further insight into the stereoselective interaction between warfarin and cimetidine in man

I Niopas  1 , S Toon, M Rowland
Affiliations

Further insight into the stereoselective interaction between warfarin and cimetidine in man

I Niopas et al. Br J Clin Pharmacol. 1991 Oct.

Abstract

The urinary profile of R- and S-warfarin, following administration of a single (25 mg) oral dose of racemic warfarin, alone or on day 4 of a 9-day chronic administration of cimetidine (800 mg once daily), was investigated in eight healthy male volunteers. Based on estimated apparent formation clearance values, cimetidine inhibited significantly only the formation of R-6-hydroxywarfarin and R-7-hydroxywarfarin.

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