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. 1977;23(3):212-7.

Changes in radiosensitivity induced by cyclic nucleotides and chemical radioprotection

F Fremuth
  • PMID: 195849

Changes in radiosensitivity induced by cyclic nucleotides and chemical radioprotection

F Fremuth. Folia Biol (Praha). 1977.

Abstract

Cyclic AMP has a radioprotective effect and its aministration results in a significant increase in LD50/30 values in Chinese hamsters. The efficiency of these radioprotective effects is comparable to that of such radioprotective compounds as AET and cystamine + mexamine. Cyclic GMP is responsible for significant radiosensitizing effects. Changes in radiosensitivity after administration of cyclic nucleotides are both immediate and delayed and correlate closely with dose and time of administration.

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