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Review
. 2009 Nov;94(11):1581-9.
doi: 10.3324/haematol.2009.008979. Epub 2009 Jul 7.

Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

Sigurdur Y Kristinsson  1 , Lynn R Goldin, Magnus Björkholm, Jill Koshiol, Ingemar Turesson, Ola Landgren
Affiliations
Review

Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

Sigurdur Y Kristinsson et al. Haematologica. 2009 Nov.

Abstract

There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.

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Figures

Figure 1.
Figure 1.
Proposed model regarding the role of immune-related and genetic factors in the pathogenesis of lymphoproliferative and plasma cell malignancies.
See this image and copyright information in PMC

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