Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Jul 8;28(13):1828-30.
doi: 10.1038/emboj.2009.180.

A histone code for the DNA damage response in mammalian cells?

Armelle Corpet  1 , Geneviève Almouzni
Affiliations
Comment

A histone code for the DNA damage response in mammalian cells?

Armelle Corpet et al. EMBO J. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
A histone code for the DNA damage response in mammalian cells. After DNA damage, histones undergo many different post-translational modifications (PTMs) that can impact on the DNA repair process itself or during the chromatin restoration step. Tjeertes et al report new findings concerning changes in histone PTMs on DNA damage (marked with *). In contrast, methylation of H3K79 and H4K20 while unchanged on DSB formation rather become accessible thereby facilitating the recruitment of checkpoint signalling proteins such as 53BP1. In addition to the changes in PTMs imposed by specific enzymatic complexes (in purple), chromatin-remodelling complexes also participate in the DNA damage response by making chromatin more accessible through histone eviction or exchange (not shown). Ac, acetylation; Me, methylation; P, phosphorylation; Ub, ubiquitination. K, lysine; S, serine; Y, tyrosine.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Corpet A, Almouzni G (2009) Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information. Trends Cell Biol 19: 29–41 - PubMed
    1. Das C, Lucia MS, Hansen KC, Tyler JK (2009) CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459: 113–117 - PMC - PubMed
    1. Groth A, Rocha W, Verreault A, Almouzni G (2007) Chromatin challenges during DNA replication and repair. Cell 128: 721–733 - PubMed
    1. Loyola A, Almouzni G (2007) Marking histone H3 variants: how, when and why? Trends Biochem Sci 32: 425–433 - PubMed
    1. Ramanathan B, Smerdon MJ (1986) Changes in nuclear protein acetylation in u.v.-damaged human cells. Carcinogenesis 7: 1087–1094 - PubMed