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Comment
. 2009 Jul 8;28(13):1828-30.
doi: 10.1038/emboj.2009.180.

A histone code for the DNA damage response in mammalian cells?

Armelle Corpet  1 , Geneviève Almouzni
Affiliations
Comment

A histone code for the DNA damage response in mammalian cells?

Armelle Corpet et al. EMBO J. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
A histone code for the DNA damage response in mammalian cells. After DNA damage, histones undergo many different post-translational modifications (PTMs) that can impact on the DNA repair process itself or during the chromatin restoration step. Tjeertes et al report new findings concerning changes in histone PTMs on DNA damage (marked with *). In contrast, methylation of H3K79 and H4K20 while unchanged on DSB formation rather become accessible thereby facilitating the recruitment of checkpoint signalling proteins such as 53BP1. In addition to the changes in PTMs imposed by specific enzymatic complexes (in purple), chromatin-remodelling complexes also participate in the DNA damage response by making chromatin more accessible through histone eviction or exchange (not shown). Ac, acetylation; Me, methylation; P, phosphorylation; Ub, ubiquitination. K, lysine; S, serine; Y, tyrosine.
See this image and copyright information in PMC

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