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Review
. 2009 Jul;9(7):975-87.
doi: 10.1586/era.09.51.

Obesity and renal cell carcinoma: epidemiology, underlying mechanisms and management considerations

Zachary Klinghoffer  1 , Brian Yang, Anil Kapoor, Jehonathan H Pinthus
Affiliations
Review

Obesity and renal cell carcinoma: epidemiology, underlying mechanisms and management considerations

Zachary Klinghoffer et al. Expert Rev Anticancer Ther. 2009 Jul.

Abstract

The incidence of both renal cell carcinoma (RCC) and obesity are steadily rising in Western societies. Recent studies have established that obesity is a significant risk factor for the development of several malignancies, including RCC. However, the mechanisms underlying this relationship remain to be fully elucidated. We review herein the epidemiological links between obesity and RCC, the potential mechanisms by which obesity can influence RCC development and progression, and the special considerations related to the treatment of obese patients with RCC.

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