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. 2009 Aug 15;49(4):591-5.
doi: 10.1086/603554.

Dexamethasone in Cryptococcus gattii central nervous system infection

Peter Phillips  1 , Kristine Chapman, Madeleine Sharp, Phil Harrison, Jerry Vortel, Theodore Steiner, William Bowie
Affiliations

Dexamethasone in Cryptococcus gattii central nervous system infection

Peter Phillips et al. Clin Infect Dis. .

Abstract

Clinical outcomes were reviewed for 4 patients with Cryptococcus gattii central nervous system infection who received dexamethasone for the treatment of persisting mental status abnormalities and focal lesions on brain scan despite culture-negative cerebrospinal fluid and the management of intracranial pressure. Favorable clinical responses were observed in 3 patients. Although corticosteroids are not recommended for the treatment of cryptococcal meningitis, these observations suggest that dexamethasone should be further evaluated in this subset of patients.

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