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. 2009 Oct;49(4):488-92.
doi: 10.1097/MPG.0b013e31819a4e2c.

Maternal HLA class I compatibility in patients with biliary atresia

Naoki Irie  1 , Toshihiro Muraji, Naoki Hosaka, Yasutsugu Takada, Seisuke Sakamoto, Kohichi Tanaka
Affiliations

Maternal HLA class I compatibility in patients with biliary atresia

Naoki Irie et al. J Pediatr Gastroenterol Nutr. 2009 Oct.

Abstract

Biliary atresia (BA) is an inflammatory cholangiopathy of unknown etiology. Maternal microchimerism has been identified in the livers of patients with BA. We analyzed the human leukocyte antigen (HLA) compatibility between 57 BA patient-mother pairs and 50 control-mother pairs. The HLA class I matching was significantly more frequent in BA pairs (odds ratio [OR]=2.46) than controls. Similar results were also found in child-to-mother HLA compatibility (OR=2.16). Our results indicate that patients with BA have an immunogenetic histocompatible relationship with their mothers, which may result in an increase in maternal microchimerism found in BA.

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