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. 2009 Aug;27(8):743-5.
doi: 10.1038/nbt.1554. Epub 2009 Jul 9.

Variation in the safety of induced pluripotent stem cell lines

Kyoko Miura  1 , Yohei Okada, Takashi Aoi, Aki Okada, Kazutoshi Takahashi, Keisuke Okita, Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe, Mari Ohnuki, Daisuke Ogawa, Eiji Ikeda, Hideyuki Okano, Shinya Yamanaka
Affiliations

Variation in the safety of induced pluripotent stem cell lines

Kyoko Miura et al. Nat Biotechnol. 2009 Aug.

Abstract

We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.

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References

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