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. 2009 Jun 12:5:30.
doi: 10.3762/bjoc.5.30.

Controlling hazardous chemicals in microreactors: synthesis with iodine azide

Johan C Brandt  1 , Thomas Wirth
Affiliations

Controlling hazardous chemicals in microreactors: synthesis with iodine azide

Johan C Brandt et al. Beilstein J Org Chem. .

Abstract

Aromatic aldehydes have been converted into the corresponding carbamoyl azides using iodine azide. These reactions have been performed safely under continuous flow reaction conditions in microreactors.

Keywords: azide; flow chemistry; hazardous reagents; microreactor; rearrangement.

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Figures

Scheme 1
Scheme 1
Azide addition to aldehydes and formation of carbamoyl azides.
Figure 1
Figure 1
Microreactor setup for the in situ generation and use of iodine azide (IN3).
Scheme 2
Scheme 2
Reaction of carbamoyl azide 4a with n-butyllithium.
See this image and copyright information in PMC

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