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. 2009;48(33):6097-100.
doi: 10.1002/anie.200902262.

Palladium(II)-catalyzed ortho alkylation of benzoic acids with alkyl halides

Yang-Hui Zhang  1 , Bing-Feng Shi, Jin-Quan Yu
Affiliations

Palladium(II)-catalyzed ortho alkylation of benzoic acids with alkyl halides

Yang-Hui Zhang et al. Angew Chem Int Ed Engl. 2009.

Abstract

The first Pd(II)-catalyzed alkylation of aryl C–H bonds is achieved without using a co-oxidant. The alkylation reaction was followed thereafter by an intramolecular lactonization to give broadly useful γ– and ™– benzolactones.

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Figures

Scheme 1
Scheme 1
Pd-Catalyzed Alkylation of Aryl C–H Bonds
Scheme 2
Scheme 2
Building Blocks Derived from Benzolactones
Scheme 3
Scheme 3
Preliminary Mechanistic Studies
See this image and copyright information in PMC

References

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