Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Oct;32(10):1904-6.
doi: 10.2337/dc09-0663. Epub 2009 Jul 10.

Maternal BMI before pregnancy, maternal weight gain during pregnancy, and risk of persistent positivity for multiple diabetes-associated autoantibodies in children with the high-risk HLA genotype: the MIDIA study

Trond Rasmussen  1 , Lars C Stene, Sven O Samuelsen, Ondrej Cinek, Turid Wetlesen, Peter A Torjesen, Kjersti S Rønningen
Affiliations

Maternal BMI before pregnancy, maternal weight gain during pregnancy, and risk of persistent positivity for multiple diabetes-associated autoantibodies in children with the high-risk HLA genotype: the MIDIA study

Trond Rasmussen et al. Diabetes Care. 2009 Oct.

Abstract

Objective: To assess whether maternal BMI before pregnancy and weight gain during pregnancy predicted the risk of islet autoimmunity in genetically susceptible children.

Research design and methods: Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positive and 885 were followed with serial blood samples tested for autoantibodies to insulin, GAD, and insulinoma-associated protein 2 (IA2). The end point was defined as repeated positivity for two or three autoantibodies or the onset of type 1 diabetes (islet autoimmunity).

Results: Thirty-six children developed islet autoimmunity, of whom 10 developed type 1 diabetes. Both maternal BMI > or =30 kg/m(2) before pregnancy and maternal weight gain > or =15 kg predicted the increased risk of islet autoimmunity (hazard ratio [HR] 2.5, P = 0.023, and HR 2.5, P = 0.015, respectively), independent of maternal diabetes.

Conclusions: Maternal weight may predict risk of islet autoimmunity in offspring with a high genetic susceptibility for type 1 diabetes.

PubMed Disclaimer

References

    1. DIAMOND Project Group. Incidence and trends of childhood type 1 diabetes worldwide 1990–1999. Diabet Med 2006;23:857–866 - PubMed
    1. Aamodt G, Stene LC, Njølstad PR, Søvik O, Joner G: The Norwegian Childhood Diabetes Study Group. Spatiotemporal trends and age-period-cohort modeling of the incidence of type 1 diabetes among children aged <15 years in Norway 1973–1982 and 1989–2003. Diabetes Care 2007;30:884–889 - PubMed
    1. Rønningen KS, Spurkland A, Iwe T, Vartdal F, Thorsby E: Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus. Tissue Antigens 1991;37:105–111 - PubMed
    1. Undlien DE, Friede T, Rammensee HG, Joner G, Dahl-Jørgensen K, Søvik O, Akselsen HE, Knutsen I, Rønningen KS, Thorsby E: HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection. Diabetes 1997;46:143–149 - PubMed
    1. Dahlquist GG: Viruses and other perinatal exposures as initiating events for beta-cell destruction. Ann Med 1997;29:413–417 - PubMed

Publication types