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. 1991 Oct;10(10):899-908.
doi: 10.3109/02713689109020325.

Corneal cell adhesion and proliferation on hydrogel sheets bound with cell-adhesive proteins

H Kobayashi  1 , Y Ikada
Affiliations

Corneal cell adhesion and proliferation on hydrogel sheets bound with cell-adhesive proteins

H Kobayashi et al. Curr Eye Res. 1991 Oct.

Abstract

The efficiency of protein immobilization to provide a hydrogel surface with a high affinity for corneal epithelial cells was investigated. The cell adhesive proteins collagen and fibronectin, and the cell adhesive oligopeptide RGDS (arginine-glycine-aspartic acid-serine) were successfully covalently immobilized on poly(vinyl alcohol) (PVA) hydrogel sheets. Corneal epithelial cells and L-929 cells were applied to these surfaces. A large number of cells did adhere and proliferate on these protein-bound surfaces in comparison with the virgin PVA not so immobilized.

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