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Review
. 2009 May;127(2):97-100.
doi: 10.1590/s1516-31802009000200008.

Artificial oxygen carriers as a possible alternative to red cells in clinical practice

Fabiano Timbó Barbosa  1 , Mário Jorge Jucá, Aldemar Araujo Castro, José Lira Duarte, Luciano Timbó Barbosa
Affiliations
Review

Artificial oxygen carriers as a possible alternative to red cells in clinical practice

Fabiano Timbó Barbosa et al. Sao Paulo Med J. 2009 May.

Abstract
in English, Portuguese

Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved in allogenic blood transfusions and they include transmission of infections, delayed postoperative wound healing, transfusion reactions, immunomodulation and cancer recurrence. Regardless of whether artificial oxygen carriers are available for routine clinical use, further studies are needed in order to show the safety and efficacy of these substances for clinical practice.

Os fluidos de ressuscitação são utilizados para abolir os distúrbios microcirculatórios e restaurar a adequada oxigenação tissular. Os limites de segurança na prática da transfusão restrita são dados pela tolerância individual do paciente na anemia normovolêmica aguda. Os transportadores artificiais de oxigênio baseados no perfluorocarbono e na hemoglobina são opções atrativas para a transfusão alogênica de células vermelhas. Os riscos da transfusão sanguínea alogênica são muitos e incluem a transmissão de infecções, retardo na cicatrização pós-operatória, reações transfusionais, imunomodulação e risco de recorrência do câncer. Independentemente de os carreadores artificiais de oxigênio estarem disponíveis para o uso clínico rotineiro, mais estudos são necessários para mostrar a segurança e a eficácia dessas substâncias na prática clínica.

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Conflict of interest statement

Conflict of interest: None

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