This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2009 Sep 10;52(17):5271-94.

doi: 10.1021/jm900552r.

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors

Yu Yu¹, Danuta S Kalinowski, Zaklina Kovacevic, Aritee R Siafakas, Patric J Jansson, Christian Stefani, David B Lovejoy, Philip C Sharpe, Paul V Bernhardt, Des R Richardson

Affiliations

PMID: 19601577
DOI: 10.1021/jm900552r

Review

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors

Yu Yu et al. J Med Chem. 2009.

. 2009 Sep 10;52(17):5271-94.

doi: 10.1021/jm900552r.

Authors

Yu Yu¹, Danuta S Kalinowski, Zaklina Kovacevic, Aritee R Siafakas, Patric J Jansson, Christian Stefani, David B Lovejoy, Philip C Sharpe, Paul V Bernhardt, Des R Richardson

Affiliation

¹ Department of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.

PMID: 19601577
DOI: 10.1021/jm900552r

No abstract available

PubMed Disclaimer

Similar articles

Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
Serda M, Kalinowski DS, Mrozek-Wilczkiewicz A, Musiol R, Szurko A, Ratuszna A, Pantarat N, Kovacevic Z, Merlot AM, Richardson DR, Polanski J. Serda M, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5527-31. doi: 10.1016/j.bmcl.2012.07.030. Epub 2012 Jul 15. Bioorg Med Chem Lett. 2012. PMID: 22858101
Effects of the ferrous chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) on the kinetics of reduction of CDP by ribonucleotide reductase of the Novikoff tumor.
Preidecker PJ, Agrawal KC, Sartorelli AC, Moore EC. Preidecker PJ, et al. Mol Pharmacol. 1980 Nov;18(3):507-12. Mol Pharmacol. 1980. PMID: 7007866 No abstract available.
Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.
Opletalová V, Kalinowski DS, Vejsová M, Kunes J, Pour M, Jampílek J, Buchta V, Richardson DR. Opletalová V, et al. Chem Res Toxicol. 2008 Sep;21(9):1878-89. doi: 10.1021/tx800182k. Epub 2008 Aug 13. Chem Res Toxicol. 2008. PMID: 18698850
Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies.
Tsimberidou AM, Alvarado Y, Giles FJ. Tsimberidou AM, et al. Expert Rev Anticancer Ther. 2002 Aug;2(4):437-48. doi: 10.1586/14737140.2.4.437. Expert Rev Anticancer Ther. 2002. PMID: 12647987 Review.
Ribonucleotide reductase inhibitors as anti-herpes agents.
Wnuk SF, Robins MJ. Wnuk SF, et al. Antiviral Res. 2006 Sep;71(2-3):122-6. doi: 10.1016/j.antiviral.2006.03.002. Epub 2006 Mar 30. Antiviral Res. 2006. PMID: 16621038 Review.

See all similar articles

Cited by

Small molecule compounds targeting the p53 pathway: are we finally making progress?
Yu X, Narayanan S, Vazquez A, Carpizo DR. Yu X, et al. Apoptosis. 2014 Jul;19(7):1055-68. doi: 10.1007/s10495-014-0990-3. Apoptosis. 2014. PMID: 24756955 Free PMC article. Review.
Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.
Popović-Bijelić A, Kowol CR, Lind ME, Luo J, Himo F, Enyedy EA, Arion VB, Gräslund A. Popović-Bijelić A, et al. J Inorg Biochem. 2011 Nov;105(11):1422-31. doi: 10.1016/j.jinorgbio.2011.07.003. Epub 2011 Jul 31. J Inorg Biochem. 2011. PMID: 21955844 Free PMC article.
Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux.
Bormio Nunes JH, Hager S, Mathuber M, Pósa V, Roller A, Enyedy ÉA, Stefanelli A, Berger W, Keppler BK, Heffeter P, Kowol CR. Bormio Nunes JH, et al. J Med Chem. 2020 Nov 25;63(22):13719-13732. doi: 10.1021/acs.jmedchem.0c01277. Epub 2020 Nov 15. J Med Chem. 2020. PMID: 33190481 Free PMC article.
Small Molecule Regulation of Iron Homeostasis: Design and Optimization of Novel Iron Chelators Based on a Thiosemicarbazone Scaffold.
Parry CS, Li Y, Kwofie SK, Valencia J, Tope Niedermaier CA, Ramadhar TR, Nekhai S, Wilson MD, Butcher RJ. Parry CS, et al. J Mol Struct. 2025 Jul 5;1334:141859. doi: 10.1016/j.molstruc.2025.141859. Epub 2025 Feb 24. J Mol Struct. 2025. PMID: 40686823
New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer.
Kontoghiorghes GJ. Kontoghiorghes GJ. Int J Mol Sci. 2022 Nov 13;23(22):13990. doi: 10.3390/ijms232213990. Int J Mol Sci. 2022. PMID: 36430469 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- American Chemical Society
Other Literature Sources
- The Lens - Patent Citations Database