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. 2009 Sep 15;25(18):10794-801.
doi: 10.1021/la901346s.

X-ray photoelectron spectroscopy- and surface plasmon resonance-detected photo release of photolabile protecting groups from nucleoside self-assembled monolayers on gold surfaces

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X-ray photoelectron spectroscopy- and surface plasmon resonance-detected photo release of photolabile protecting groups from nucleoside self-assembled monolayers on gold surfaces

Katja Drexler et al. Langmuir. .

Abstract

The formation of self-assembled monolayers (SAMs) on gold by 2-(5-iodo-2-nitrophenyl) propoxycarbonyl (I-NPPOC)-protected thymidine with an attached mercaptohexyl succinate linker and the kinetics of photochemical release of the I-NPPOC group were monitored using X-ray photoelectron spectroscopy (XPS) and surface plasmon resonance (SPR) detection. In the XPS spectra, the iodine peaks allowed for specific and accurate monitoring of the presence and loss of I-NPPOC groups on the surface. In the SPR experiment, the overall signal change on photoillumination is in accord with a theoretical estimation of the density of I-NPPOC groups in a dense monolayer. The kinetics roughly follow a biexponential time dependence with two very different time constants, corresponding to photochemical quantum yields of 0.22 and 0.0032, respectively.

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