Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Jul 17;31(1):5-7.
doi: 10.1016/j.immuni.2009.06.011.

IL-33 raises alarm

Mohamed Lamkanfi  1 , Vishva M Dixit
Affiliations
Free article
Comment

IL-33 raises alarm

Mohamed Lamkanfi et al. Immunity. .
Free article

Abstract

The interleukin-1 (IL-1)-like cytokine IL-33 is widely assumed to undergo proteolytic maturation by caspase-1. In this issue of Immunity, Lüthi et al. (2009) show that IL-33 is not a caspase-1 substrate. IL-33 is inactivated by caspase-3 and -7 to prevent an inappropriate immune response during apoptosis, but not in necrosis.

PubMed Disclaimer

Comment on

LinkOut - more resources