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Comment
. 2009 Jul 17;31(1):7-9.
doi: 10.1016/j.immuni.2009.07.001.

Integr-ating IL-1 alpha in antiviral host defenses

Katherine A Fitzgerald  1
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Free article
Comment

Integr-ating IL-1 alpha in antiviral host defenses

Katherine A Fitzgerald. Immunity. .
Free article

Abstract

Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity.

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