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. 2009;64(7):691-7.
doi: 10.1590/S1807-59322009000700014.

The role of oxidative stress and lipid peroxidation in ventricular remodeling induced by tobacco smoke exposure after myocardial infarction

Daniella R Duarte  1 , Marcos F Minicucci, Paula S Azevedo, Beatriz B Matsubara, Luiz S Matsubara, Ethel L Novelli, Sergio A R Paiva, Leonardo A M Zornoff
Affiliations

The role of oxidative stress and lipid peroxidation in ventricular remodeling induced by tobacco smoke exposure after myocardial infarction

Daniella R Duarte et al. Clinics (Sao Paulo). 2009.

Abstract

Objective: To evaluate the roles of oxidative stress and lipid peroxidation in the ventricular remodeling that is induced by tobacco smoke exposure after myocardial infarction.

Methods: After induced myocardial infarction, rats were allocated into two groups: C (control, n=25) and ETS (exposed to tobacco smoke, n=24). After 6 months, survivors were submitted to echocardiogram and biochemical analyses.

Results: Rats in the ETS group showed higher diastolic (C = 1.52 +/- 0.4 mm(2), ETS = 1.95 +/- 0.4 mm(2); p=0.032) and systolic (C = 1.03 +/- 0.3, ETS = 1.36 +/- 0.4 mm(2)/g; p=0.049) ventricular areas, adjusted for body weight. The fractional area change was smaller in the ETS group (C = 30.3 +/- 10.1 %, ETS = 19.2 +/- 11.1 %; p=0.024) and E/A ratios were higher in ETS animals (C = 2.3 +/- 2.2, ETS = 5.1 +/- 2.5; p=0.037). ETS was also associated with a higher water percentage in the lung (C = 4.8 (4.3-4.8), ETS = 5.5 (5.3-5.6); p=0.013) as well as higher cardiac levels of reduced glutathione (C = 20.7 +/- 7.6 nmol/mg of protein, ETS = 40.7 +/- 12.7 nmol/mg of protein; p=0.037) and oxidized glutathione (C = 0.3 +/- 0.1 nmol/g of protein, ETS = 0.9 +/- 0.3 nmol/g of protein; p=0.008). No differences were observed in lipid hydroperoxide levels (C = 0.4 +/- 0.2 nmol/mg of tissue, ETS = 0.1 +/- 0.1 nmol/mg of tissue; p=0.08).

Conclusion: In animals exposed to tobacco smoke, oxidative stress is associated with the intensification of ventricular remodeling after myocardial infarction.

Keywords: Coronary occlusion; Heart failure; Hypertrophy; Ventricular dilatation; Ventricular function.

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Figures

Figure 1
Figure 1
Left ventricle diastolic area ratio (short axis/long axis), an index of chamber geometry. ETS: exposed to tobacco smoke. p> 0.05.
Figure 2
Figure 2
GSH/GSSG ratio. ETS: exposed to tobacco smoke. * p<0.05.
See this image and copyright information in PMC

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