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Review
. 2009 Aug;37(Pt 4):897-904.
doi: 10.1042/BST0370897.

53BP1: function and mechanisms of focal recruitment

Jennifer E FitzGerald  1 , Muriel Grenon, Noel F Lowndes
Affiliations
Review

53BP1: function and mechanisms of focal recruitment

Jennifer E FitzGerald et al. Biochem Soc Trans. 2009 Aug.

Abstract

53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

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