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. 2009 Apr;11(4):201-6.
doi: 10.1111/j.1751-7176.2009.00096.x.

Blood pressure goals and arterial stiffness in chronic kidney disease

YinPing Liew  1 , Mohammed A Rafey, Sridhar Allam, Susana Arrigain, Robert Butler, Martin Schreiber
Affiliations

Blood pressure goals and arterial stiffness in chronic kidney disease

YinPing Liew et al. J Clin Hypertens (Greenwich). 2009 Apr.

Abstract

The association of optimal blood pressure (BP) control and arterial stiffness was evaluated in 172 patients with chronic kidney disease. The authors compared the augmentation index (AIx) of patients who achieved a recommended BP goal (<130/80 mm Hg) with those who did not (> or = 130/80 mm Hg). The median age was 57 years, 60% were male, and 70% were Caucasian. One-third of patients had achieved a BP goal of <130/80 mm Hg. AIx was significantly lower in patients who achieved BP goal than in those who did not (median AIx, 19% vs 23%; P=.04). AIx remained significantly lower in patients who achieved the BP goal, after adjusting for age, sex, and height (mean effect on AIx, -3.3%; 95% confidence interval, -6.1% to -0.4%; P=.03). Achievement of BP goal of <130/80 mm Hg in chronic kidney disease patients is associated with significantly lower AIx and may reflect a reduction in overall arterial stiffness.

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Figures

Figure
Figure
Central aortic waveform and augmentation index (AIx). (A) Forward waveform; (B) reflected waveform; (C) summation waveform as the result of early wave reflection in a patient with stiff arteries.
See this image and copyright information in PMC

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